modafinil will lessen the level or outcome of mavacamten by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. tecovirimat will improve the amount or effect of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Keep an eye on. Tecovirimat is a weak inhibitor of CYP2C8 and CYP2C19. Keep an eye on for ad